Avelox (Moxifloxacin)

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Moxifloxacin: Side Effects Moxifloxacin is an 8-methoxyquinolone with enhanced potency against important Gram-positive pathogens, notably Streptococcus pneumoniae (penicillin-resistant and penicillin-susceptible strains), and class activity against Gram-negative bacteria. Its activity is not affected by beta-lactamases. Moxifloxacin may therefore represent a promising alternative for treatment of respiratory tract infections. Dosage adjustment is not required for patients of advanced age or those with renal or mild hepatic impairment. Drug interactions with moxifloxacin have been reviewed. Observational studies In a phase I trial, single-dose pharmacokinetics of moxifloxacin have been reported after oral administration of 50-800 mg in 45 healthy Caucasian men. Moxifloxacin was well tolerated. There were no serious adverse events, dropouts, or deaths. Only […]

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Moxifloxacin: Organs and Systems Cardiovascular Moxifloxacin blocks the rapid-component delayed-rectifier potassium channel in the heart, and thus prolongs the QTC interval by 6 minutes after oral administration and 12 minutes after intravenous administration. Moxifloxacin carries a greater risk of QT interval prolongation than ciprofloxacin, levofloxacin, and ofloxacin, and although the risk of moxifloxacin-induced tor-sade de pointes is expected to be minimal when the drug is given in the recommended dosage (400 mg/day), moxifloxacin should be used with caution in patients with prodysrhythmic conditions and avoided in patients taking antidysrhythmic drugs, such as quinidine, procainamide, amiodarone, and sotalol. A man developed a hypertensive crisis and transient left bundle branch block with QT […]