Diflucan (Fluconazole)

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Concurrent administration of fluconazole probably causes increased exposure to amitriptyline. Three reports of adults have shown increased amitriptyline plasma concentrations with concurrent administration of fluconazole; in one patient, a 57-year-old woman, the QT interval was prolonged and torsade de pointes occurred. In vitro studies and experiments in animals have given conflicting results relating to potential antagonism between the effects of fluconazole and amphotericin on Candida species.

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In a group of children with fever, neutropenia, and neoplastic disease, there was an increase in renal fluconazole clearance. In infants and children, the volume of distribution of fluconazole is significantly higher and falls with age. With the exception of infants, who have a slower clearance rate, children clear the compound more rapidly. However, a second larger study reported slower elimination in children under 1 year of age, requiring dosage adjustments.

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Dizziness, headache, and seizures were seen in 2-5% of 232 patients with severe systemic fungal infections taking fluconazole. In the same group there were three cases each of delirium and dysesthesia (1.3%).

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It’s not certain why some women get vaginal yeast infections and others don’t. Certain risk factors — which may include taking antibiotics, using oral contraceptives, and having uncontrolled diabetes — may contribute to creating an imbalance in the vaginal environment. When that happens, there can be an overgrowth of Candida, a yeast that is normally a harmless part of the vaginal environment. The overgrowth of Candida can lead to a vaginal yeast infection.

Yeast infection basics

That’s because about 75% of women will have at least 1 vaginal yeast infection during their lifetime. About half of these women have more than one. Fortunately, most yeast infections aren’t serious — especially if you get the right treatment. But symptoms of a yeast infection — which may include vaginal itching, burning, abnormal discharge — can easily be confused with those of other vaginal infections.

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