Prescription Drugs

Itraconazole 100 mg Capsules (Sporanox)

Like other azoles, it interferes with the cytochrome P-450-dependent enzyme, 14a-demethylase. This leads to 14-methylsterol accumulation and ergosterol depletion in fungal cells and this results in alterations in a number of membrane-associated cell functions. Itraconazole has a broad spectrum of action including Aspergillus species, Blastomyces dermatitidis, Candida species, Coccidioides immitis, Cryptococcus neoformans, Histoplasma capsulatum, Paracoccidioides brasiliensis, Scedosporium apiospermum and Sporothrix schenckii.

Use and Administration of Itraconazole 100 mg (Sporanox)

Itraconazole can be used to treat various superficial fungal infections, including the dermatophytoses, pityriasis versicolor, and mucosal and cutaneous forms of candidosis. It is also effective in patients with subcutaneous infections, such as chromoblastomycosis, sporotrichosis and certain forms of phaeohyphomycosis.

Pharmacokinetics of Itraconazole 100 mg Capsules (Sporanox)

Absorption of itraconazole from the gastrointestinal tract is incomplete (about 55%), but is improved if the drug is given with food. Oral administration of a single 100-mg capsule will produce peak serum concentrations of between 0.1 and 0.2mg/l about 2-4 h later. Higher concentrations are obtained after repeated dosing, but there is marked variation between individuals. As with ketoconazole, there is a disproportionate increase in blood levels with increasing dosage.

Fluconazole 50, 100, 150, 200 mg Tablets (Diflucan)

Fluconazole is a potent inhibitor of ergosterol biosynthesis, through its action on the cytochrome P-450-dependent enzyme, lanosterol 14a-demethylase. Depletion of ergosterol, the principal sterol in the membrane of susceptible fungal cells, and accumulation of methylated sterols leads to alterations in a number of membrane-associated cell functions. Fluconazole has a broad spectrum of action including Blastomyces dermatitidis, Coccidioides immitis, Cryptococcus neoformans, Histoplasma capsulatum and Paracoccidioides brasiliensis. It is active against Candida albicans, C. tropicalis and C. parapsilosis, but many strains of C. krusei and Torulopsis glabrata (now reclassified as Candida glabrata) appear to be insensitive.

Drug Interactions of Fluconazole 50, 100, 150, 200 mg Tablets (Diflucan)

Unlike itraconazole and ketoconazole, absorption of fluconazole is not reduced if it is given together with drugs that reduce gastric acid secretion. Concomitant administration of fluconazole and rifampicin has resulted in a modest reduction in blood levels of the antifungal agent. The effect is less marked than with itraconazole or ketoconazole and is due to induction of P-450 cytochrome oxidases by rifampicin with resulting enhanced hepatic metabolism of the azole drug. Like rifampicin, phenytoin undergoes cytochrome P-450-mediated hepatic metabolism and its concomitant administration with fluconazole may reduce its clearance.

Ciprofloxacin 250mg, 500mg, 750mg Tablets [Cipro, Ciproxin]

Ciprofloxacin belongs to a group of medicines known as the quinolone antibacterials, fluoroquinolones. It has high anti-bacterial activity against a wide range of organisms. Contact your doctor immediately, if any of the following occurs while taking Ciprofloxacin.

Clarithromycin 250mg, 500mg Tablets [US: Biaxin]

Clarithromycin belongs to a group of medicine called macrolide antibiotics. Antibiotics stop the growth of bacteria (bugs) which cause infections. Clarithromycin tablets are used to treat following infections: chest infections such as bronchitis and pneumonia, throat and sinus infections, skin and soft tissue infections, helicobacterpylori infections associated with duodenal ulcers.

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