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Albendazole is authorised in the world under the following brand names: Albenza, Eskazole, Valbazen, Zentel.

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Intestinal Nematode Infections

Worldwide, more than 1 billion people are infested with Ascaris lumbricoides, the causative agent of ascariasis or roundworm. More than 4 million people are estimated to be infected in the United States. Infection occurs predominately in the southeastern states and more commonly in younger children, and it is associated with lower socioeconomic status. The organism is acquired through ingestion of embryonic forms of the worm, which are found in fecally contaminated soil.

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Since neurocysticercosis is a neurological infection, it is not surprising that when treating it with any drug some of the neurological reactions to that drug (or to the death of the parasite) are particularly pronounced. For example, with a dose of 1.5 mg/kg continued for some time in cases of neurocysticercosis, a majority of patients initially develop intolerance in the form of headache, vomiting, fever, and occasionally diplopia and meningeal irritation.

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The use of albendazole and mebendazole in patients with hydatidosis has been evaluated in 448 patients with E. granulosis hydatid cysts who received continuous treatment with albendazole 10-12 mg/kg/day for 3-6 months daily orally in a total dose of (323 patients) twice or mebendazole 50 mg/kg/day. At the end of treatment, 82% of the cysts treated with albendazole and 56% of the cysts treated with mebendazole showed degenerative changes.

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Albendazole has been used in the treatment of human hookworm and trichuriasis. In a mass-treatment report from Western Australia 295 individuals in a remote rural area were treated with albendazole 400 mg/day for 5 days because of possible Giardia lamblia and hookworm infections. The 37% prevalence of Giardia fell to 12% between days 6 and 9, but rose again to 28% between days 18 and 30. The effect on hookworms (Ankylostoma duodenale) was more pronounced and more sustained with a reduction of the pretreatment prevalence of hookworm infections from 76% before treatment to 0% after 3^1 weeks.

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Albendazole is used in the treatment of tissue infections caused by the larval forms of certain cestodes (tapeworms) including neurocysticercosis caused by Cysticercus cellulosae, the larval form of Taenia solium (pork tapeworm). Albendazole also is used for the treatment of hydatid disease caused by the larval form of Echinococcus granulosus (dog tapeworm). Other anthelmintics (usually praziquantel) are used for the treatment of intestinal infections caused by adult forms of cestodes. Albendazole is used for the treatment of parenchymal neurocysticercosis resulting from active lesions caused by Cysticercus cellulosae, the larval form of Taenia solium (pork tapeworm), preferably in combination with corticosteroids.

Dosage forms of Albendazole:
Albenza 200 mg tablet Albendazole powder

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Therapeutic classes of Albendazole:

Anthelmintics, Anticestodal Agents, Antiprotozoal Agents, Tubulin Modulators

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