Tags: Amphotericin B

Leishmania

The genera Leishmania and Trypanosoma are members of the family Trypanosomatidae. These protozoans cause diseases with widely varied clinical presentations as well as geographic distributions, including leishmaniasis, American trypanosomiasis (Chagas’ disease), and African trypanosomiasis (sleeping sickness).

Pathogenic Amebas

There are numerous distinct species of ameba within the genus Entamoeba, and the majority of these do not cause disease in humans. E histolytica is a pathogenic species that is capable of causing disease, such as colitis or liver abscess, in humans. E dispar is prevalent and is indistinguishable from E histolytica by conventional laboratory methods. E dispar exists in humans in only an asymptomatic carrier state and does not cause colitis.

Fusarium, Penicillium, Paracoccidioides, & Agents of Chromomycosis

Fusarium spp. is an emerging fungal pathogen. Although long recognized as a cause of local infection involving nails, traumatized skin, or the cornea (eg, in contact lens wearers), deep or disseminated infection was not described until the mid 1970s. Despite its worldwide distribution and its frequent recovery from soil and vegetative material, infection is quite rare. Only ~ 100 cases involving invasive disease in immunosuppressed patients have been described in the medical literature.

Chromomycosis

Chromomycosis, also known as chromoblastomycosis, is a chronic subcutaneous infection caused by several different fungi. Although rarely seen in the United States, it is common worldwide. Chromomycosis occurs worldwide but is most frequently encountered in tropical and subtropical regions. The most common occurrence is in barefoot individuals, particularly among agricultural workers.

Paracoccidioidomycosis

Paracoccidioidomycosis is caused by Paracoccidioides brasiliensis. Also known as South American blastomycosis, it is the most prevalent systemic mycosis found in Central and South America and is the most common endemic mycosis in this area. Paracoccidioidomycosis is acquired only in Central and South America and ranges from Mexico to Argentina.

Penicillium Infections

Penicillium spp. are ubiquitous in nature and may be recovered with ease from a variety of sources within the hospital environment. These molds commonly contaminate clinical specimens and cause contamination in the laboratory. Colonization of nonsterile anatomical sites in humans is common. In most cases where Penicillium spp. are recovered from clinical specimens, they represent colonization.

Aspergillus, Pseudallescheria, & Agents of Mucormycosis

Aspergillus spp. are found worldwide and grow in a variety of conditions. They commonly grow in soil and moist locations and are among the most common molds encountered on spoiled food and decaying vegetation, in compost piles, and in stored hay and grain. Aspergillus spp. often grow in houseplant soil, and such soil may be a source of Aspergillus conidia or spores in the home, office, or hospital setting. The airborne conidia are extremely heat resistant and can withstand extreme environmental conditions.

Mucormycosis: Clinical Syndromes

Rhinocerebral mucormycosis occurs most commonly in patients with uncontrolled diabetes, especially after an episode of diabetic ketoacidosis. It may also occur in leukemic patients who have had prolonged neutropenia and therapy with broad-spectrum antibiotics and occasionally in organ transplant recipients. The earliest symptoms in rhinocerebral mucormycosis are facial pain, headache, and nasal stuffiness.

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