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Cefaclor is authorised in the world under the following brand names: Alenfral, Alfacet, Alfatil, Ceclor, Ceclor CD, Distaclor, Kefral, Panacef, Panoral, Raniclor.

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Branhamella Catarrhalis: Clinical Syndromes

B catarrhalis causes bronchitis and pneumonia in patients with underlying lung disease, especially chronic obstructive pulmonary disease. It is also a rare cause of invasive disease, including meningitis, endocarditis, bacteremia without a focus, septic arthritis, and cellulitis.

Streptococcus Pyogenes

Streptococcus pyogenes is a human pathogen without an animal reservoir. Group A streptococci (GAS) cause most streptococcal disease, but other groups are important pathogens in some settings (Box 1). Group A streptococcal infections have the highest incidence in children younger than age 10. The asymptomatic prevalence is also higher (15-20%) in children, compared with that in adults (<5%).

Anti-Infective Agent Dosing

The characteristics that need to be considered when administering antibiotics include absorption (when dealing with oral antibiotics), volume of distribution, metabolism, and excretion. These factors determine the dose of each drug and the time interval of administration. To effectively clear a bacterial infection, serum levels of the antibiotic need to be maintained above the minimum inhibitory concentration for a significant period. For each pathogen, the minimum inhibitory concentration is determined by serially diluting the antibiotic into liquid medium containing 104 bacteria per millihter.

Specific Anti-Infective Agents

Clinicians should be familiar with the general classes of antibiotics, their mechanisms of action, and their major toxicities. The differences between the specific antibiotics in each class can be subtle, often requiring the expertise of an infectious disease specialist to design the optimal anti-infective regimen. The general internist or physician-in-training should not attempt to memorize all the facts outlined here, but rather should read the pages that follow as an overview of anti-infectives. The chemistry, mechanisms of action, major toxicities, spectrum of activity, treatment indications, pharmacokinetics, dosing regimens, and cost are reviewed.

Urinary Tract Infections and Prostatitis

A urinary tract infection is defined as the presence of microorganisms in the urine that cannot be accounted for by contamination. The organisms have the potential to invade the tissues of the urinary tract and adjacent structures.

Skin and Soft Tissue Infections

Impetigo is a superficial skin infection that is seen most commonly in children. It is highly communicable and spreads through close contact. Most cases are caused by S. pyogenes, but S. aureus either alone or in combination with S. pyogenes has emerged as a principal cause of impetigo.

Respiratory Tract Infections, Upper

The goals of treatment include reduction in signs and symptoms, eradication of infection, and prevention of complications. Avoidance of unnecessary antibiotic use is another goal in view of S. pneumonia. dClindamycin is only recommended in cases of documented S. pneumoniae. It is not effective against H. influenzae or M. catarrhalis.

Respiratory Tract Infections, Lower

Bronchitis, bronchiolitis, pneumonia clinical presentation and treatment.

Antimicrobial Regimen Selection

A generally accepted systematic approach to the selection and evaluation of an antimicrobial regimen is shown in Table Systematic Approach for Selection of Antimicrobials. An «empiric» antimicrobial regimen is begun before the offending organism is identified, while a «definitive» regimen is instituted when the causative organism is known. The use of combinations to prevent the emergence of resistance is widely applied but not often realized. The only circumstance where this has been clearly effective is in the treatment of tuberculosis.

Antimicrobial therapy: general principles

A wide variety of antimicrobial agents is available to treat established infections caused by bacteria, fungi, viruses, or parasites. This section will cover the general principles of antimicrobial therapy and will also include illustrative clinical problems to emphasize proper decision-making in using antimicrobials.

Dosage forms of Cefaclor:
Raniclor 250 mg chewable tablet Cefaclor 250 mg capsule Raniclor 375 mg chewable tablet Ceclor 250 mg pulvule
Cefaclor CR 500 mg 12 Hour tablet Cefaclor 500 mg capsule Ceclor 500 mg pulvule Cefaclor 125 mg/5ml Suspension 75ml Bottle
Cefaclor 187 mg/5ml Suspension 50ml Bottle Cefaclor 375 mg/5ml Suspension 50ml Bottle Cefaclor 187 mg/5ml Suspension 100ml Bottle Cefaclor 250 mg/5ml Suspension 75ml Bottle
Cefaclor 125 mg/5ml Suspension 150ml Bottle Ceclor 250 mg/5ml Suspension 75ml Bottle Ceclor 125 mg/5ml Suspension 150ml Bottle Ceclor 187 mg/5ml Suspension 100ml Bottle
Ceclor 15 250 mg capsule Bottle Cefaclor 250 mg/5ml Suspension 150ml Bottle Cefaclor 375 mg/5ml Suspension 100ml Bottle Ceclor 250 mg/5ml Suspension 150ml Bottle
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Synonyms of Cefaclor:

CCL, Cefaclor Anhydrous, Cefaclorum [INN-Latin], Cephaclor

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