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Clindamycin is authorised in the world under the following brand names: Chlolincocin, Cleocin, Cleocin Hcl, Cleocin Pediatric, Cleocin Phosphate, Cleocin T, Cleocin T Gel, Cleocin T Lotion, Cleocin T Topical Solution, Clinda-Derm, Clindagel, Clindesse, Clindets, Clinimycin, Dalacin, Dalacin C, Dalacin C Flavored Granules, Dalacin C Phosphate, Dalacin T Topical Solution, Evoclin, ResiDerm A, Sobelin, Zindaclin.

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Babesiosis

Several other drugs have been evaluated, including tetracycline, primaquine, sulfadiazine (Microsulfon) and pyrimethamine (Fansidar). Results have varied. Pentamidine (Pentam) has proved to be moderately effective in diminishing symptoms and decreasing parasitemia. Others: High-level parasitemia is more common in asplenic patients.

Anaerobic & Necrotizing Infections

Gangrene is local death of soft tissues due to disease or injury and is associated with loss of blood supply. Anaerobic and necrotizing infections may be associated with gas.

Specific Anti-Infective Agents

Clinicians should be familiar with the general classes of antibiotics, their mechanisms of action, and their major toxicities. The differences between the specific antibiotics in each class can be subtle, often requiring the expertise of an infectious disease specialist to design the optimal anti-infective regimen. The general internist or physician-in-training should not attempt to memorize all the facts outlined here, but rather should read the pages that follow as an overview of anti-infectives. The chemistry, mechanisms of action, major toxicities, spectrum of activity, treatment indications, pharmacokinetics, dosing regimens, and cost are reviewed.

Antimicrobial therapy: general principles

A wide variety of antimicrobial agents is available to treat established infections caused by bacteria, fungi, viruses, or parasites. This section will cover the general principles of antimicrobial therapy and will also include illustrative clinical problems to emphasize proper decision-making in using antimicrobials.

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The drug also is active in vitro against Arcanobacterium haemolyticum (formerly Corynebacterium haemolyticum). Clindamycin is active against some anaerobic and microaerophilic gram-negative and gram-positive organisms including Actinomyces, Bacteroides, Eubacterium, Fusobacterium, Propionibacterium, microaerophilic streptococci, Peptococcus, Peptostreptococcus, and Veillonella. Clindamycin is active in vitro against Prevotella and Porphyromonas (both formerly classified as Bacteroides); Mobiluncus (motile, anaerobic, curved rods) also are inhibited in vitro by the drug. Clostridium perfringens, C. tetani, Corynebacterium diphtheriae, and Mycoplasma are also inhibited by clindamycin.

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Adverse GI effects frequently occur with oral, IM, or IV clindamycin and may be severe enough to necessitate discontinuance of the drug. Adverse GI effects of clindamycin include nausea, vomiting, diarrhea, abdominal pain, and tenesmus.

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Clindamycin hydrochloride and clindamycin palmitate hydrochloride are administered orally. Clindamycin phosphate is administered by IM injection or by intermittent or continuous IV infusion. Clindamycin hydrochloride capsules and clindamycin palmitate hydrochloride oral solution can be administered without regard to food. To avoid the possibility of esophageal irritation, clindamycin hydrochloride capsules should be administered orally with a full glass of water.

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Clindamycin generally is used for the treatment of serious infections caused by susceptible gram-positive bacteria and for the treatment of serious infections caused by susceptible anaerobic bacteria. Because the risk of severe, potentially fatal Clostridium difficile-associated diarrhea and colitis may be higher with clindamycin than with certain other anti-infectives, use of the drug should be limited to serious infections for which less toxic and/or more effective anti-infectives are not readily available. However, it should be noted that C. difficile diarrhea and colitis has been associated with the use of nearly all anti-infectives, being reported most frequently with clindamycin, cephalosporins, and ampicillin; second and third generation cephalosporins play an increasingly important role.

Dalacin C [Cleocin-US] (Clindamycin hydrochloride) 75mg,150mg Tablets

Dalacin does not get into the brain and is therefore not suitable for treating serious infections in and around the brain. Your doctor may need to give you another antibiotic if you have these infections. Some medicines can affect the way this medicine works, or the medicine itself can reduce the effectiveness of other medicines taken at the same time. These include:

Successful Antibiotic Desensitization

Antibiotics are often an essential component of the therapeutic plan that is developed to improve the clinical course of a patient. Typically, certain antibiotics are better for a given clinical condition. Allergies to these antibiotics, however, may limit the use of these antibiotics and in certain cases may complicate the course of optimal care. Allergies to antibiotics have become an great hindrance to the clinician.

Dosage forms of Clindamycin:
Apo-Clindamycin 300 mg Capsule Mylan-Clindamycin 300 mg Capsule Novo-Clindamycin 300 mg Capsule Dalacin C 150 mg Capsule
Clindets 1% pledgets Clindamycin hcl 150 mg capsule Clindamycin 2% vaginal cream Clindamax 2% vaginal cream
Clindamycin ph 300 mg/2 ml vial Cleocin t 1% gel Cleocin phos 150 mg/ml vial Cleocin 2% vaginal cream
Clindamycin 150 mg/ml addvan Dalacin C 300 mg Capsule Cleocin hcl 75 mg capsule Cleocin hcl 150 mg capsule
Clindamycin (60 & 120 Ml) 150 mg/ml Clindamycin 150 mg/ml Clindamycin phosphate 1% foam Clindamycin hcl 300 mg capsule
Dalacin C Phosphate 150 mg/ml Cleocin 150 mg capsule Clindagel 1% gel Evoclin 1% foam
Clindamycin phos crystals Cleocin hcl 300 mg capsule Clindamycin Phosphate 1% Solution 30ml Bottle Clindamycin phosphate powdr
Clindamycin Phosphate 1% Solution 60ml Bottle Clindamycin Phosphate 1% Gel 30 gm Tube Clindesse 2% vaginal cream Clindamycin Phosphate 1% Lotion 60ml Bottle
Clindamycin Phosphate 60 1% Swab Box Clindamycin Phosphate 2% Cream 40 gm Tube Cleocin-T 1% Gel 30 gm Tube Cleocin-T 1% Solution 60ml Bottle
Clindamycin Phosphate 1% Gel 60 gm Tube Clindamycin hcl crystals Cleocin 75 mg/5ml Solution 100ml Bottle Cleocin 3 100 mg Suppository Box
Cleocin 2% Cream 40 gm Tube Cleocin-T 60 1% Swab Box Cleocin-T 1% Lotion 60ml Bottle Cleocin-T 1% Gel 60 gm Tube
Clindamycin Phos-Benzoyl Perox 1-5% Gel 50 gm Jar Clindamycin Phosphate 1% Foam 50 gm Can Clindagel 1% Gel 40ml Bottle Evoclin 1% Foam 50 gm Can
Clindamycin Phosphate 1% Foam 100 gm Can Evoclin 1% Foam 100 gm Can Clindagel 1% Gel 75ml Bottle Dalacin C Palmitate 15 mg/ml Solution
Cleocin 600 mg-d5w-galaxy Cleocin 900 mg-d5w-galaxy Clinda-derm 1% solution Apo-Clindamycin 150 mg Capsule
Mylan-Clindamycin 150 mg Capsule Novo-Clindamycin 150 mg Capsule Clindamycin ph 9 g/60 ml vial  

Synonyms of Clindamycin:

Clindamicina [INN-Spanish], Clindamycin, Clindamycin Hcl, Clindamycin Hydrochloride, Clindamycin Phosphate, Clindamycine [French], Clindamycine [INN-French], Clindamycinum [INN-Latin]

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Therapeutic classes of Clindamycin:

Anti-Bacterial Agents, Lincomycins, Protein Synthesis Inhibitors

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