Tags: Co-trimoxazole

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Co-trimoxazole is authorised in the world under the following brand names: Bactrim.

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Paracoccidioidomycosis

Paracoccidioidomycosis is caused by Paracoccidioides brasiliensis. Also known as South American blastomycosis, it is the most prevalent systemic mycosis found in Central and South America and is the most common endemic mycosis in this area. Paracoccidioidomycosis is acquired only in Central and South America and ranges from Mexico to Argentina.

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Amoxicillin, an acid stable, semi-synthetic drug belongs to a class of antibiotics called the Penicillins (beta-lactam antibiotics). It is shown to be effective against a wide range of infections caused by wide range of Gram-positive and Gram-negative bacteria in both human and animals.

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Concurrent administration of fluconazole probably causes increased exposure to amitriptyline. Three reports of adults have shown increased amitriptyline plasma concentrations with concurrent administration of fluconazole; in one patient, a 57-year-old woman, the QT interval was prolonged and torsade de pointes occurred. In vitro studies and experiments in animals have given conflicting results relating to potential antagonism between the effects of fluconazole and amphotericin on Candida species.

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Dizziness, headache, and seizures were seen in 2-5% of 232 patients with severe systemic fungal infections taking fluconazole. In the same group there were three cases each of delirium and dysesthesia (1.3%).

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Torsade de pointes and cardiorespiratory arrest have been reported in a patient with congenital long QT syndrome who took azithromycin. In a prospective study of 47 previously healthy people, there was a modest statistically insignificant prolongation of the QTC interval without clinical consequences after the end of a course of azithromycin 3 g/day for 5 days. Azithromycin can cause ototoxicity. In one study, 8 (17%) of 46 HIV-positive patients had probable (n = 6) or possible (n = 2) ototoxicity with azithromycin.

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Administration of amantadine in patients receiving drugs with anticholinergic activity may result in increased adverse anticholinergic and CNS effects. When amantadine is administered to patients already near the limit of tolerance for anticholinergic agents, atropinism with nocturnal confusion and hallucinations may gradually develop. It has been suggested that the dosage of the anticholinergic agent be reduced prior to the initiation of amantadine therapy or that the dose of either drug be reduced if atropine-like adverse effects appear.

Dapsone (Aczone)

The most frequent adverse effects of dapsone are dose-related hemolytic anemia and methemoglobinemia. Hemolysis occurs in most patients receiving 200 mg or more of dapsone daily; however, symptomatic anemia occurs only occasionally. The manufacturer states that the hemoglobin level is generally decreased by 1-2 g/dL, the reticulocyte count is increased 2-12%, erythrocyte life span is shortened, and methemoglobinemia occurs in most patients receiving dapsone. Heinz body formation also occurs frequently.

Dapsone (Aczone): Uses

Dapsone is used in rifampin-based multiple-drug regimens for the treatment of multibacillary and paucibacillary leprosy. Although dapsone was used alone in the past for the treatment of leprosy, the World Health Organization (WHO) and most clinicians currently recommend that rifampin-based multiple-drug regimens be used for the treatment of all forms of leprosy. Multiple-drug regimens may reduce infectiousness of the patient more rapidly as well as delay or prevent the emergence of resistant organisms. Rifampin-based regimens are necessary because of the increasing incidence of dapsone-resistant Mycobacterium leprae, and these regimens are designed to be effective against all strains of M. leprae, regardless of their susceptibility to dapsone.

Rifampin: Uses

Rifampin is used in conjunction with other antituberculosis agents for the treatment of clinical tuberculosis.

Antituberculosis Agents General Statement

Antituberculosis agents are antibiotics and synthetic anti-infectives used in the treatment of tuberculosis and other diseases caused by organisms of the genus Mycobacterium. Isoniazid, rifampin, ethambutol, and pyrazinamide are the drugs used most frequently in the treatment of tuberculosis and are considered first-line agents for use in antituberculosis regimens.

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