Tags: Griseofulvin

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Griseofulvin is authorised in the world under the following brand names: Amudane, Biogrisin-fp, Curling factor, Delmofulvina, Fulcin, Fulcine, Fulvican grisactin, Fulvicin, Fulvicin P/G, Fulvicin U/F, Fulvina, Fulvinil, Fulvistatin, Fungivin, Greosin, Gresfeed, Gricin, Grifulin, Grifulvin, Grifulvin V, Gris-PEG, Grisactin, Grisactin Ultra, Griscofulvin, Grisefuline, Griseo, Griseofulvin forte, Griseomix, Grisetin, Grisofulvin, Grisovin, Grisovin FP, Grizeofulvin, Grysio, Guservin, Lamoryl, Likuden, Likunden, Murfulvin, Neo-Fulcin, Neocid, Poncyl, Spirofulvin, Sporostatin, Sporostatin xan, Xuanjing.

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Dermatophytes

Dermatophytes are molds that infect keratinized tissues including skin, hair, and nails. Whereas 40 dermatophyte species are known to infect humans, only about 15 of these are common causes of disease. These organisms belong to three genera, Microsporum, Trichophyton, and Epidermophyton. Because these fungi have such similar infectivity, morphology, and pathogenicity, they are often categorized according to the clinical syndrome and the preferred anatomic site with which they are associated, such as tinea capitis, tinea pedis, etc.

Management of Tinea Unguium (Amorolfine, Tioconazole, Itraconazole, Griseofulvin)

Fungal infection of the nails (onychomycosis) may be caused by a number of dermatophytes as well as by a number of other moulds and Candida species. There is wide geographical and racial variation in the causative agents, but in the UK 85-90% of nail infections are due to dermatophytes and about 5% are due to non-dermatophyte moulds.

Management of Tinea Corporis (Griseofulvin, Terbinafine, Itraconazole)

Tinea corporis is caused by E. floccosum and many species of Trichophyton and Microsporum. Infection with anthropophilic species, such as E. floccosum or T. rubrum often follows autoinoculation from another infected body site, such as the feet. Tinea corporis caused by T. tonsurans is sometimes seen in children with tinea capitis and their close contacts. Tinea corporis commonly occurs following contact with infected household pets or farm animals, but occasional cases result from contact with wild mammals or contaminated soil.

Management of Tinea Capitis (Terbinafine, Itraconazole)

The condition is worldwide in distribution, but is most prevalent in Africa, Asia and southern and eastern Europe, where it is the most common form of dermatophytosis. Improved standards of hygiene and prompt eradication of sporadic infection have led to a marked decline in the incidence of tinea capitis in North America and western Europe.

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Headache is the most common adverse effect of griseofulvin. It occurs in about 50% of patients and can be severe. Drowsiness, dizziness, fatigue, confusion, depression, irritability, and insomnia have also been observed. Impaired co-ordination and unsteadiness while walking have been reported in some cases when there was confusion.

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Dizziness, headache, and seizures were seen in 2-5% of 232 patients with severe systemic fungal infections taking fluconazole. In the same group there were three cases each of delirium and dysesthesia (1.3%).

Dosage forms of Griseofulvin:
Griseofulvin powder Gris-peg 125 mg tablet Gris-peg 250 mg tablet Grifulvin v 500 mg tablet
Griseofulvin Microsize 125 mg/5ml Suspension 120ml Bottle      

Synonyms of Griseofulvin:

Griseofulvina [INN-Spanish], Griseofulvine [INN-French], Griseofulvinum [INN-Latin]

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Therapeutic classes of Griseofulvin:

Antibacterial Agents, Antibiotics, Antifungal

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