Tags: Kantrex

Antimicrobial therapy: general principles

A wide variety of antimicrobial agents is available to treat established infections caused by bacteria, fungi, viruses, or parasites. This section will cover the general principles of antimicrobial therapy and will also include illustrative clinical problems to emphasize proper decision-making in using antimicrobials.

Kanamycin Sulfate

IM and IV dosage are identical and should be based on an estimate of ideal body weight. The manufacturers state that dosage by all routes of administration should not exceed 1.5 g daily. A causal relationship between maintenance of certain peak or trough serum concentrations or other pharmacodynamic endpoints and clinical response or toxicity has not been established to date for aminoglycoside dosing regimens. However, in general, desirable peak serum concentrations of kanamycin for systemic infections are 15-30 mcg/mL and trough concentrations of the drug should not exceed 5-10 mcg/mL.

Kanamycin Acid Sulfate

Kanamycin is an aminoglycoside antibacterial with actions similar to those of gentamicin. It has been used in the treatment of susceptible Gram-negative and staphylococcal infections, including gonorrhoea and neonatal gonococcal eye infections, although its use has declined in many centres because of the development of resistance.