Tags: Mebendazole

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Mebendazole is authorised in the world under the following brand names: Bantenol, Besantin, Equivurm Plus, Lomper, MBDZ, Mebendazole (JAN/USP), Mebendazole(USAN), MEBENDAZOLE, 99%, Mebenoazole, Mebenvet, Mebex, Mebutar, Noverme, Ovitelmin, Pantelmin, Telmin, Vermicidin, Vermirax, Vermox, Vermox (TN), Verpanyl.

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Cestodes

Human infections caused by cestodes, or tapeworms, may occur within the lumen of the bowel, where adult cestodes attach themselves to the host intestine (Box 1). Alternatively, human infection may be the result of dissemination of cestodes from the bowel to involve extraintestinal sites, often by larval forms of the parasite. The life cycle of cestodes is determined by definitive hosts, in whom the mature adult worm lives, and intermediate hosts, which harbor the larval forms of the parasite. Humans are a definitive host for six cestodes: Diphyllobothrium latum, Taenia solium, Taenia saginata, Hymenolepis diminuta, Hymenolepis nana, and Dipylidium caninum.

Nematodes

Nematodes (roundworms) are nonsegmented, tapered, bilaterally symmetrical, cylindrical organisms that have complete digestive tracts and reproduce sexually. Although > 500,000 species of nematodes have been described, only a small number are commonly encountered as human parasites. Most nematodes have complex life cycles, sometimes involving several larval forms and intermediate hosts or free-living stages. The pathogenic nematodes may be categorized as primarily intestinal or extraintestinal tissue parasites (Box 1).

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Since neurocysticercosis is a neurological infection, it is not surprising that when treating it with any drug some of the neurological reactions to that drug (or to the death of the parasite) are particularly pronounced. For example, with a dose of 1.5 mg/kg continued for some time in cases of neurocysticercosis, a majority of patients initially develop intolerance in the form of headache, vomiting, fever, and occasionally diplopia and meningeal irritation.

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The use of albendazole and mebendazole in patients with hydatidosis has been evaluated in 448 patients with E. granulosis hydatid cysts who received continuous treatment with albendazole 10-12 mg/kg/day for 3-6 months daily orally in a total dose of (323 patients) twice or mebendazole 50 mg/kg/day. At the end of treatment, 82% of the cysts treated with albendazole and 56% of the cysts treated with mebendazole showed degenerative changes.

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Albendazole has been used in the treatment of human hookworm and trichuriasis. In a mass-treatment report from Western Australia 295 individuals in a remote rural area were treated with albendazole 400 mg/day for 5 days because of possible Giardia lamblia and hookworm infections. The 37% prevalence of Giardia fell to 12% between days 6 and 9, but rose again to 28% between days 18 and 30. The effect on hookworms (Ankylostoma duodenale) was more pronounced and more sustained with a reduction of the pretreatment prevalence of hookworm infections from 76% before treatment to 0% after 3^1 weeks.

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Mebendazole, a benzimidazole, is poorly absorbed from the gut, although it dependably enters cyst fluid; it is therefore most useful for treating intestinal infections and cyst-forming infestations. It is essentially an antihelminthic drug, being effective against hookworm, ascariasis, enterobiasis, and trichuriasis. Mebendazole is effective against enteric Strongyloides but since it is not absorbed it is ineffective against tissue forms. However, it is also effective against Giardia lamblia, while Trichomonas vaginalis is susceptible in vitro.

Dosage forms of Mebendazole:
Vermox 100 mg Chewable Tablet Mebendazole powder Mebendazole 100 mg tablet chew Mebendazole 100 mg Chew Tabs

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Therapeutic classes of Mebendazole:

Antinematodal Agents, Tubulin Modulators

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