Tags: penicillins

Penicillins: Organs and Systems: Immunologic

Anaphylactic shock can occur, even after oral administration of penicillin and skin testing. However, anaphylactic shock is less common after oral than parenteral administration. In one study the incidence of anaphylactic shock was 0.04% of all patients treated with penicillin. It is also low in patients receiving long-term benzathine penicillin (1.2 million units every 4 weeks).

Penicillins: Organs and Systems: Skin

Skin reactions are the commonest adverse effects of therapeutically administered penicillins. Penicillin-contaminated milk or meat can cause itching or generalized skin reactions or even anaphylaxis. The overall annual incidence of severe erythema multi-forme (toxic epidermal necrolysis and Stevens-Johnson syndrome) is about one case per million, antibiotics being involved in 30-40%. The clinical differentiation between these syndromes can be difficult.

Penicillins: Organs and Systems: Liver

Penicillin-induced hepatotoxicity may not be as uncommon as has been thought. There have been three reviews. The first was a comparison of the assessment of drug-induced liver injury obtained by two different methods, the Council for International Organizations of Medical Sciences (CIOMS) scale and the Maria & Victorino (M&V) clinical scale. Three independent experts evaluated 215 cases of hepatotoxicity reported using a structured reporting form.

Penicillins: Organs and Systems: Hematologic

Since the days when chloramphenicol was more commonly used, it has been recognized that many antimicrobial drug are associated with severe blood dyscrasias, such as aplastic anemia, neutropenia, agranulocytosis, throm-bocytopenia, and hemolytic anemia. Information on this association has come predominantly from case series and hospital surveys (38^. Some evidence can be extracted from population-based studies that have focused on aplastic anemia and agranulocytosis and their association with many drugs, including antimicrobial drugs. The incidence rates of blood dyscrasias in the general population have been estimated in a cohort study with a nested case-control analysis, using data from a General Practice Research Database in Spain.

Order Chloromycetin (Chloramphenicol) No Prescription 250mg

Chloramphenicol is one of the older broad-spectrum antibiotics. It was introduced in 1948 and grew in popularity because of its high antimicrobial activity against a wide range of Gram-positive and Gram-negative bacteria, Rickettsiae, Chlamydia, and Mycoplasma species. It is particularly useful in infections caused by Salmonella typhi and Haemophilus influenzae. It is mainly bacteriostatic.

Buy Generic Minocin (Minocycline) No Prescription 100mg

The syndrome of pseudotumor cerebri consists of symptoms and signs of raised intracranial pressure in the absence of neuroimaging or cerebrospinal fluid abnormalities. Most cases are idiopathic, but several drugs have been implicated as causative or contributory. The first description of minocycline-related pseudotumor cerebri was published in 1978. Further data have been published concerning 12 patients who developed pseudotumor cerebri after taking standard doses of minocycline for acne vulgaris.

Brucellosis

Systemic bacterial infection caused by Brucella species in infected animal products, or vaccine. Incubation period usually 5-60 days, but highly variable and may be several months.

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