Tags: Retrovir

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Toxoplasma Gondii

Toxoplasma gondii infection, or toxoplasmosis, is a zoonosis (the definitive hosts are members of the cat family). The two most common routes of infection in humans are by oral ingestion of the parasite and by transplacental (congenital) transmission to the fetus. Ingestion of undercooked or raw meat that contains cysts or of water or food contaminated with oocysts results in acute infection.

Toxoplasma Gondii: Treatment

Immunocompetent adults and children with toxoplasmic lymphadenitis do not require treatment unless symptoms are severe or persistent. Infections acquired by laboratory accident or transfusion of blood products are potentially more severe, and these patients should always be treated. The combination of pyrimethamine, sulfadiazine, and folinic acid for 4-6 weeks is the most commonly used and recommended drug regimen (Box 2).

Cryptococcus Neoformans

Cryptococcus neoformans exists as two distinct varieties known as variety neoformans and variety gattii (Table 1). Cryptococcus neoformans variety neoformans exists throughout the world and is found frequently in pigeon droppings that have accumulated over time. The concentrations of these organisms are often quite high in old pigeon droppings found in barns, on window ledges, and around the upper floors of old buildings. Pigeons carrying the organism do not seem to be clinically affected, and wet or fresh droppings rarely contain C neoformans.

HIV & Other Retroviruses

Two major groups of retroviruses are considered in this chapter: the oncoviruses (“onco-,” related to a tumor) and the lentiviruses (“lenti-,” slow). Oncoviruses have long been associated with a variety of cancers in animals, including leukemia, lymphoma, and sarcoma; however, until recent years, oncoviruses had not been found to infect humans. The first human retrovirus, human T-lymphotropic virus type 1 (HTLV-1), was discovered in the late 1970s. It was shown to cause adult T-cell leukemia, a rare malignancy found only in Japan, Africa, and the Caribbean (although serologic evidence shows that the virus also occurs in the United States and may be associated with some chronic neurologic conditions).

Candidiasis Mucocutaneous

A mucocutaneous disorder caused by infection with various species of Candida. Candida is normally present, in very small amounts, in the oral cavity, gastrointestinal tract, and female genital tract. Genetics: Chronic mucocutaneous candidiasis is a heterogeneous clinical syndrome that usually presents in childhood and can have an autosomal recessive, dominant or sporadic mode of inheritance. Sera from HIV-infected patients with thrush have been screened for C. albicans genomic expression.

Anti-Infective Therapy

Despite dire warnings that we are approaching the end of the antibiotic era, the incidence of antibiotic-resistant bacteria continues to rise. The proportions of penicillin-resistant Streptococcus pneumoniae, hospital-acquired methicillin-resistant Staphylococcus aureus, and vancomycin-resistant Enterococcus strains continue to increase. Community-acquired methicillin-resistant Staphylococcus aureus is now common throughout the world.

Skin and Soft Tissue Infections

Impetigo is a superficial skin infection that is seen most commonly in children. It is highly communicable and spreads through close contact. Most cases are caused by S. pyogenes, but S. aureus either alone or in combination with S. pyogenes has emerged as a principal cause of impetigo.

HIV / AIDS

P. carinii pneumonia is the most common life-threatening opportunistic infection in patients with AIDS. The taxonomy of the organism is unclear, having been classified as both protozoan and fungal.

Treatment of HIV / AIDS

The goal of antiretroviral therapy is to achieve the maximum suppression of HIV replication (HIV RNA level that is less than the lower limit of quantitation). Secondary goals include an increase in CD4 lymphocytes and an improved quality of life. The ultimate goal is decreased morbidity and mortality.

Dosage forms of Zidovudine:
Retrovir iv infusion vial Retrovir 100 mg capsule Zidovudine 300 mg tablet Retrovir 300 mg tablet
Retrovir 50 mg/5ml Syrup 240ml Bottle      

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Therapeutic classes of Zidovudine:

Anti-HIV Agents, Antimetabolites, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors, Reverse Transcriptase Inhibitors

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